Dota Auto Chess is the most crucial part of the entire Dota Auto Chess mode and subdivided into two, Race and Class.
Race Dota Auto Chess
| Race | Synergy | Heroes |
| Dragon | 3- All dragons start fighting with 100 mana. | Viper, Puck, Dragon Knight, |
| Dwarf | Attack range increased by 300. | Sniper, Gyrocopter |
| Elements | Increase the magic resistance of all allied elements by 20. | Razor, Enigma, Morphling, Tiny |
| Troll | 2/4 – increase attack speed of allied trolls by 30/all allies by 30. | Shadow Shaman, Bar Rider, Witch Doctor, Troll |
| Undead | 2/4 – reducing the armor of all enemies by 5/7. | Drow Ranger, Abaddon, Necrophos, Lich |
| Beast | 2/4/6 – Attack increased by 10/15/20% for all allies. | Tusk, Venomancer, Sand King, Lone Druid, Lycan |
| Naga | 2/4 – increasing the magic resistance of all allies by 20/40. | Slardar, Slark, Medusa, Tide Hunter |
| Ogre | Increase in maximum health by 10%. | Ogre Magi |
| Orc | 2/4 – increase the health of all ogres by 250/350. | Ace, Beast Master, Juggernaut, Disruptor |
| Demon | Attack increased by 50% if the demon of only one type is on the battlefield. With two Hunter Demons, we can eliminate this anti-synergy. | Pain Queen, Chaos Knight, Shadow Fiend, Doom, Terrorblade |
| Elf | 2 – increase dodge by 20% for allied elves. | Anti-Mage, Puck, Treant Protector, Luna, Furion, Wind Ranger, Phantom Assassin, Templar Assassin |
| Goblin | 3/6 – Armor and life regeneration increased by 15 for a random ally/by 15 for all goblins. | Bounty Hunter, Clockwerk, Tinker, Timbersaw, Alchemist, Techies |
| Human | 2/4/6 – 20/25/30% chances of disarming the opponent for 3 seconds. | Crystal, Lycan, Omni Knight, Lina, Kunkka, Light Keeper, Dragon Knight |
Class Dota Auto Chess
| Class | Synergy | Heroes |
| Mage | 3/6 – decrease magic resistance of all enemies by 30/50. | Razor, Puck, Crystal, Lina, Light Keeper, Ogre Magi, Lich |
| Warrior | 3/6 – increases allied units’ armor by 8/10. | Tusk, Doom, Lycan, Kunkka, Slardar, Axe, Juggernaut, Troll, Tiny |
| Druid | Easier development. | Enchantress, Lone Druid, Treant Protector, Furion |
| Hunter | 3/6 – attack of allied hunters increased by 25/35% | Sniper, Wind Ranger, Medusa, Tide Hunter, Beast Master, Drow Ranger |
| Knight | 2/4/6 – knight ally has 25/35/45% chances for getting a shield. | Chaos Knight, Luna, Omni Knight, Dragon Knight, Bat Rider, Abaddon |
| Mech | 2/4 – increase HP regeneration of allied mechs by 15/25. | Gyrocopter, Clockwork, Tinker, Timbersaw, Techies |
| Shaman | Turns the enemy into a chicken at the beginning of the fight. | Disruptor, Shadow Shaman |
| Warlock | 3/6 – increases health drain by 20/30%. | Venomancer, Shadow Fiend, Enigma, Alchemist, Witch Doctor, Necrophos |
| Assassin | 3/6 – All assassins have 10/20% chances for dealing x4 damage. | Sand King, Pain Queen, Viper, Phantom Assassin, Templar Assassin, Bounty Hunter, Slark, Morphling |
| Demon Hunter | It counts as a demon of an opponent. Two Hunter Demons eliminate the anti-synergy of allied demons. | Anti-Mage, Terrorblade |
Read more: Dota Auto Chess Combo